iMedPub Journals ARCHIVES OF CLINICAL MICROBIOLOGY

Title: Multi-system organ failure following administration of yellow fever vaccine: a case report Background: Yellow fever vaccine-associated viscerotropic disease (YEL-AVD), is an extremely rare and life-threatening condition that occurs shortly after administration of the vaccine. It is characterized by multi-system organ failure including hemorrhagic fever, shock, renal failure, and hepatic failure. Case: A 77-year-old Caucasian male experienced multi-system organ failure within seven days of receiving the yellow fever vaccine. The patient’s signs and symptoms included fever, acute renal failure, hepatitis, lymphocytopenia, thrombocytopenia, hypotension, and respiratory failure. Conclusions: Since serious adverse events are possible following administration of yellow fever vaccine, physicians should administer the vaccine only to those truly at risk for exposure to the virus. Julie Ehret Leal, PharmD1, Amy N. Thompson, PharmD, BCPS2,Joseph D. Thomas, MD3, Walter A. Brzezinski, MD4 iMedPub Journals ARCHIVES OF CLINICAL MICROBIOLOGY 2010